Researchers and scientists from the Texas Health Science Centre at San Antonio (UT Health San Antonio) University in the US have developed two molecules that possess the ‘scissor’ enzyme of the coronavirus SARS-CoV-2-PLpro.
How does the enzyme inhibitor work as ‘scissor’?
According to the study, the enzyme inhibitor can block a particular protein so that the coronavirus cannot make a replica of itself and destroy the immune system by depending on that protein.
SARS-CoV-2-PLpro senses and processes viral proteins and thus promotes further infection. This enzyme molecule works in a double role. On one hand, it releases that particular protein for the coronavirus to replicate itself, and on the other, it also alerts the immune system to attack the infection.
This happens because this enzyme molecule releases cytokines and chemokines that helps to detect. The enzyme acts as a molecular scissor because it makes its way through the proteins ubiquitin and ISG15 and keeps the protein integrity maintained.
Why it is effective?
The enzyme inhibitors work effectively and efficiently because it has been developed in a way that senses SARS-CoV-2-PLpro but does not affect any other proteins in human cells. The inhibitors only react to the viral enzyme.
According to the belief of the researchers, the inhibitors may come in use to prepare therapeutic dosages based on these and may enhance the medicinal value. They are still going through various experiments.
After the thorough process and evaluating the similarities and differences, the researchers are concluding that it is possible to develop new modified inhibitors that can be used effectively against other deadly viruses.