Israeli scientist finds a way to cure deadly brain cancer. Tel Aviv University (TAU) have announced a groundbreaking discovery in understanding and treating one of the most lethal brain cancers, Glioblastoma.
“Glioblastoma is the deadliest type of cancer in the central nervous system, accounting for most malignant brain tumours,” said Prof. Ronit Satchi-Fainaro, Director of the Cancer Biology Research Center and the Head of the Cancer Research at Tel Aviv University.
Israeli scientist finds a way to cure deadly brain cancer
“It is aggressive, invasive, and fast-growing, making it resistant to existing treatments, with patients dying within a year of cancer’s onset. Moreover, Glioblastoma is defined as a ‘cold tumour,’ which means that it does not respond to immunotherapeutic attempts to activate the immune system against it.”
Just 40% of Glioblastoma patients survive a year after diagnosis, and only 5% survive five years, along with surgery, radiotherapy, and chemotherapy.
Initially, the researchers found an unexpected defect in the brain’s immune system that, rather than regulating the spread of cancer cells, aided cell division and spread of Glioblastoma cancer cells.
This was partially due to the release of P-selectin (SELP), a protein that usually aids cell movement inside the body.
Researchers were able to inhibit the secretion of the SELP protein in the next stage after identifying the problem, neutralizing the immune system’s breakdown, restoring its normal function, and stopping the spread of this incurable aggressive cancer.
The Tel Aviv University team worked with the Tel Aviv Sourasky Medical Center, which provided Glioblastoma tissue samples obtained during surgery, as well as neurosurgeons from Johns Hopkins University and the Lieber Institute in the United States, who provided stable brain tissues obtained from autopsies.
Satchi-Fainaro suggests that the research may have life-saving medicinal effects and that now that the drug inhibiting SELP is effective in humans, a clinical trial could be approved reasonably quickly.